Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866)
Merck Sharp & Dohme LLC

active not recruiting

Urinary Bladder Neoplasms,Muscle Neoplasms

NCT03924856
A Study to Test the Safety of Immunotherapy With Nivolumab Alone or With Ipilimumab Before Surgery for Bladder Cancer Patients Who Are Not Suitable for Chemotherapy
Memorial Sloan Kettering Cancer Center

recruiting

Urinary Bladder Neoplasms

NCT03520491
Treating Muscle-invasive Bladder Cancer With A Non-surgical Method Consisting of Anti-PD-1 Therapy and Chemoradiation
Sun Yat-sen University

not yet recruiting

Urinary Bladder Neoplasms

NCT05975307
Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303)
Merck Sharp & Dohme LLC

recruiting

Urinary Bladder Neoplasms,Muscle Neoplasms

NCT03924895
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Patients With High-Risk Muscle-Invasive Bladder Cancer Who Are ctDNA Positive Following Cystectomy
Hoffmann-La Roche

recruiting

Urinary Bladder Neoplasms

NCT04660344
BLASST-1 (Bladder Cancer Signal Seeking Trial): Nivolumab, Gemcitabine, and Cisplatin in Treatment of Muscle Invasive Bladder Cancer (MIBC) Undergoing Cystectomy
Masonic Cancer Center, University of Minnesota

completed

Urinary Bladder Neoplasms

NCT03294304
Checkpoint Inhibitor and Radiation Therapy in Bulky, Node-Positive Bladder Cancer
University of Texas Southwestern Medical Center

recruiting

Urinary Bladder Neoplasms

NCT04779489
a Genome-based Platform to Predict Patients That Can Achieve Bladder Preservation in Muscle Invasive Bladder Cancer Patients
Yonsei University

not yet recruiting

Urinary Bladder Neoplasms

NCT04686149
Pembrolizumab and Combination Chemotherapy Before Surgery for the Treatment of Muscle-Invasive Bladder Cancer
University of Washington

recruiting

Urinary Bladder Neoplasms

NCT04383743
Sacituzumab Govitecan Before Radical Cystectomy for the Treatment of Non-Urothelial Muscle Invasive Bladder Cancer
University of Washington

recruiting

Urinary Bladder Neoplasms

NCT05581589